ALETHEIA, for regulators

A regulator-readable map of what this product is, where its data comes from, and how to consult on it.

ALETHEIA is the chemistry-compound side of Holistic Quality. 1,886 compounds, 959 materials, 1,287 products — each with regulatory classification, exposure-pathway data, and risk synthesis across 13 exposure contexts.

The classifications you see in ALETHEIA come from a chain of regulatory bodies and authoritative databases — IARC monograph entries, EPA IRIS reference values, OEHHA Prop 65 listings, ECHA REACH evaluations, OECD test-guideline derived endpoints — surfaced through Holistic Quality’s signed-manifest provenance regime. Every export carries an envelope notice, a manifest digest, and a methodology link so a regulator can verify what we are publishing about their work.

What ALETHEIA is, for regulators

ALETHEIA is best read as a structured secondary-source layer over a fixed set of authoritative primary sources. It does not generate new toxicology; it normalizes, weights, and exposes the disagreement structure across the regulatory record that already exists.

We publish a public Regulator Bill of Rights describing the commitments we extend to any agency whose output we reference: notice before publication of new framings, free-of-charge consultation access, a public Engagement Registry of every regulator contact, and a manifest-verification path any agency staffer can run themselves against any of our published exports.

Where ALETHEIA data comes from

The chemistry record is sourced from the following authorities. Each row deep-links to that agency’s entry in the Holistic Quality regulator agency directory.

Source	Role in ALETHEIA
IARC	Monograph carcinogenicity classifications (Group 1 / 2A / 2B / 3) — the largest single body of regulatory-class references in the dataset.
EPA IRIS	Reference doses (RfD), reference concentrations (RfC), and oral slope factors used in the synthesis layer’s magnitude weighting.
OEHHA	California Proposition 65 listings (carcinogen / reproductive toxicant) and Safe Harbor levels (NSRL / MADL) — load-bearing for the U.S. consumer-product surface.
ECHA	REACH registration data, SVHC candidate list, CLP harmonized classifications — the EU’s regulatory backbone for ALETHEIA’s European surface.
EFSA	Food-contact compound evaluations and pesticide active-substance reviews feeding the food-tier product layer.
OECD	Test Guidelines (TG 401 / 423 / 425 / 471 / others) used to qualify methodology-dimension weighting of primary studies cited by the agencies above.

For regulator consultation

ALETHEIA’s underlying governance lives on the umbrella holisticquality.io domain. Six pages, all linkable and quotable:

Commitments

Regulator Bill of Rights

The full text of what every agency whose output we reference is entitled to from us.

Pricing

Regulator Pricing

Free consultation access for in-scope agency staffers. No paywall on the chemistry surface for regulator use.

Advisory

Regulator Advisory Board

Standing seats, charter, and the substantive review path for framings before they go public.

Registry

Engagement Registry

Public log of every regulator engagement — who, when, what was discussed, what changed.

Verify

Verify a Manifest

Self-serve CLI + web tool to verify the signed manifest on any ALETHEIA export against our published key.

Agency Directory

Every regulatory body referenced by ALETHEIA or its sister products, with scope notes and contact paths.

What ALETHEIA is NOT

Not a regulatory authority. ALETHEIA references the regulatory record; it does not set, displace, or speak for any agency’s position.
Not a substitute for primary-source review. Every classification we surface links back to the originating monograph, IRIS file, listing notice, REACH dossier, or test-guideline citation. Read the source.
Not a substitute for consulting the regulators themselves. Where a question is jurisdictional, contested, or moving, the right answer is to speak with the agency — the directory and engagement registry exist to make that easy, not to replace it.

Contact

For regulator inquiries on the chemistry surface specifically (this subdomain): regulator@holisticquality.io. For umbrella governance, advisory-board nominations, or cross-product engagement, the same address routes correctly — it is the canonical singular regulator inbox across the Holistic Quality property family.

Or fill out our intake form at https://holisticquality.io/regulator-intake — the form routes to the same inbox and gives you a structured audit trail of your submission.

Engagements are logged to the public Engagement Registry by default. Off-the-record consultation is available on request per the Bill of Rights.